A reversed-phase-liquid chromatographic (RP-HPLC) method was developed for the
determination of Cinitapride and Pantoprazole Sodium in their marketed formulation. A reversed-phase C-
18 column (250 mm × 4.60 mm i.d., particle size 5 µm) with mobile phase consisting of acetonitrile : water :
Triethylamine (80:20:0.05) was used. The flow rate was 1.2 ml/ min and effluents were monitored at 260 nm.
The retention times of Cinitapride and Pantoprazole Sodium were found to be 5.26 ± 0.10 min and 1.72 ± 0.10 min, respectively. The method was validated in terms of linearity, range, accuracy, precision, limit of detection (LOD) and limit of quantitation (LOQ). The method showed good linearity in the range of 12-28 µgm/ml for Cinitapride and 24-56 µgm/ml for Pantoprazole Sodium. The % recoveries of Cinitapride and Pantoprazole Sodium were found to be between 99.52 - 99.85% and 99.38 – 99.74 % respectively. The
percentage RSD for the method precision was found to be less than 2%. The proposed method was successfully applied to the estimation of Cinitapride and Pantoprazole Sodium in combined capsule dosage forms.
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Triethylamine (80:20:0.05) was used. The flow rate was 1.2 ml/ min and effluents were monitored at 260 nm.
Effects of CinitaprideThe retention times of Cinitapride and Pantoprazole Sodium were found to be 5.26 ± 0.10 min and 1.72 ± 0.10 min, respectively. The method was validated in terms of linearity, range, accuracy, precision, limit of detection (LOD) and limit of quantitation (LOQ). The method showed good linearity in the range of 12-28 µgm/ml for Cinitapride and 24-56 µgm/ml for Pantoprazole Sodium. The % recoveries of Cinitapride and Pantoprazole Sodium were found to be between 99.52 - 99.85% and 99.38 – 99.74 % respectively. The
percentage RSD for the method precision was found to be less than 2%. The proposed method was successfully applied to the estimation of Cinitapride and Pantoprazole Sodium in combined capsule dosage forms.
Read the full article: sphinxsai.com
gastroesophageal reflux disease is common issue due to smoking ,drinking or change of life style.it will cause the severe heart burning.to treat acid reflus Pantoprazole is most people are using to avoid heart burning.
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